Sobizana Mngqikana was born in East London, South Africa in 1938. He grew up as a young trumpeter. As many other ANC leaders and activists he studied at Fort Hare University. In 1961, a year after the ANC was banned, he became active in the underground structures of the organisation.
He joined ANC staff in 1969 and in 1973 opened a mission in Sweden in line with ANC’s strategy of “rainbow politics”, to seek to broaden support, as was described in an article by Håkan Thörn. He served the ANC as Ambassador to Turkey, Finland and other countries.